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100	1		_aMULLINAX Ross A
245			_aAntigen testing for COVID-19 asymptomatic screening: _bwhy it should be preferred over PCR insights from navy region Japan's experience with a comprehensive antigen testing strategy / _cRoss A Mullinax
260			_c2022
520			_aPolymerase chain reaction (PCR) is commonly used in asymptomatic screening testing, but is suboptimal for this purpose as it will identify many old persistent positives that are no longer infectious. This can result in placement of individuals that are not infectious to others into isolation. This results in substantial adverse impact to military manning and operations, without any benefit to public health. Antigen testing does not have this same drawback. Antigen testing, while less sensitive than PCR, will identify the vast majority of infectious positives, especially those with higher viral loads that are more likely to transmit to others. Importantly, use of antigen testing will also greatly increase the certainty of benefit from isolation, reducing the risk of isolating those individuals who are beyond their infectious period and pose no threat to public health. The literature on this topic is reviewed, with particular focus on studies that perform viral culture in addition to PCR and antigen testing. This allows for determination of sensitivity for infectious virus. Also, Navy Region Japan's experience with a comprehensive antigen testing strategy is described. The challenges presented by persistent positive PCR test results are examined, as well as the real-world benefits from implementing widespread use of antigen testing.
650			_aPOLYMERASE CHAIN REACTION _xANTIGENS _xMILITARY PERSONNEL _xVIRAL LOAD RESULT _xPUBLIC HEALTH MEDICINE _xVIRUSES _xPERSISTENCE _xRISK REDUCTION _xVIRAL CULTURE _xLABORATORY TEST FINDING _xNAVY _xCOVID-19 _zJAPAN
773			_aMilitary Medicine: International Journal of AMSUS : _gVol 187 Issue 3/4, March/April 2022, pp.68-72 (72)
598			_aCOVID-19, MILITARY, HEALTH
856			_uhttps://academic.oup.com/milmed/article/187/3-4/68/6360366 _zClick here for full text
945			_i67417.1001 _rY _sY
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